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Safe Acetaminophen Dosing For Adults

It is important to note that maximum daily doses and labeling instructions differ between Canada and the United States. The information provided below is applicable to product sold in Canada only.

This table shows examples of maximum daily ADULT doses for various pain relievers sold in Canada. Always carefully read and follow the label directions before using any over the counter medication. Click here for dosing on TYLENOL® pediatric products.


Pain reliever

Maximum daily dose

Daily maximum number of caplets/tablets

Extra Strength Acetaminophen (e.g. Extra Strength TYLENOL®)

4000 mg


8 tablets (500 mg each)

Regular Strength Acetaminophen (e.g. Regular Strength TYLENOL®)

4000 mg

12 tablets (325 mg each)

Naproxen (e.g. Aleve®)

440 mg

2 caplets (220 mg each)

Regular Strength ASA
(e.g. Aspirin®)

4000 mg

12 tablets (325 mg each)

TYLENOL® Arthritis Pain

3900 mg

6 caplets per day (650 mg Extended Release Caplets)

Ibuprofen 200 mg (e.g. ADVIL® Regular Strength/MOTRIN® Regular Strength)

1200 mg

6 caplets (200 mg each)

Ibuprofen 300 mg (e.g. MOTRIN® Extra Strength)

1200 mg

4 caplets (300 mg each)

Ibuprofen 400 mg (e.g. ADVIL® Extra Strength/MOTRIN® Super Strength)

1200 mg

3 caplets (400 mg each)


Visit www.GetReliefResponsibly.ca for a list of other common medicines you may be taking that contain acetaminophen. Get medical help or contact a local Poison Control Centre right away if you suspect an overdose, even if you do not have any symptoms, including: increased sweating, nausea, vomiting, stomach pain and/or loss of appetite.

Click here for more information on Poison Control Centres in Canada.

Exceeding the Recommended Dosage

In case of overdose, you should get medical help right away or contact your local Poison Control Centre, even if you do not notice any possible signs or symptoms such as increased sweating, nausea, vomiting, stomach pain and/or loss of appetite.

Click here for more information on Poison Control Centres in Canada.

Various Tylenol products

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How To Get Relief Responsibly® With TYLENOL®

Learn more about safe acetaminophen usage.